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Predict the fracture,
protect the patient.

PathFRAX reads the routine CT scans (e.g. CT chest, abdomen, and pelvis) your patients already receive, identifying the vertebrae most likely to fracture months before they do.

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1

The Problem

Metastatic spinal fractures cost the U.S. over $1 billion a year,1 and most are preventable.

84.6%

of high-risk patients are missed before their fracture2

The turning point

A metastatic vertebral fracture means pain, lost mobility, hospitalization, and a sharply higher risk of death.3

No standard of care

Risk is judged with subjective, unvalidated methods like the SINS score, so results vary from clinician to clinician.4

A missed window

Most high-risk patients miss the time to intervene with non-operative or minimally invasive preventative care.2

~200K

U.S. spinal metastasis patients / year5

1 in 8

Will suffer a spinal fracture6

50%

Result in inpatient admission2

2×

Higher risk of death after fracture7

Case Example

Time to intervene

High-risk vertebra (T4)

Sagittal CT with an arrow on the T4 vertebra, flagged as high risk

Missed impending fracture

2 months later

Intervention window

The window to act was missed

Fracture

The same T4 vertebra two months later, now fractured

Without intervention

2

The Solution

PathFRAX™

Management of the metastatic spine continues to evolve toward early, preventative approaches.8 However, no significant advances have been made in identifying patients at risk for fractures who should undergo preventative interventions.9

PathFRAX is designed to address this gap by providing a repeatable, accurate metric of risk that is readily available to all providers on the cancer care team.

Sagittal CT of the spine in the PathFRAX viewer with one thoracic vertebra highlighted orange

Results

Vertebra is at high risk of fracture in 3 months.

See how PathFRAX works →

Identifying missed patients

PathFRAX aims to capture the currently missed high-risk patients so interventions can take place before the fracture.

No new images

PathFRAX utilizes the CTs, such as CT chest/abdomen/pelvis, your patient already has and can be run on past or present images.

Enabling patient-specific, data-driven care decisions

PathFRAX aims to provide clinicians and patients with the data to create personalized care plans.

3

The Benefits

Patients

A solution that won’t let you go missed until it’s too late.

We aim to provide patients with early, objective risk stratification.

Physicians

A solution to inform your management.

We aim to give cancer providers early, objective data on fracture risk to inform consults, interventions, and patient discussions.

Payers

A solution to reduce cost.

We aim to reduce costs by reducing VCF incidence and high-cost inpatient stays and open surgical procedures.

Let us prevent the preventable.

Bring earlier, more certain fracture care to your patients.

Get in touch →

References:

1. Schulman KL, et al. Cancer. 109(11):2334-2342 (2007).2. Flores AR, Hamre T, Tom M, et al. Poster presented at: Congress of Neurological Surgeons (CNS) Annual Meeting; October 11, 2025; Los Angeles, CA.3. Rees-Punia E, et al. JAMA Oncol. 9(1):79-87 (2023).4. Kim YR, et al. Sci Rep. 11(1):5553 (2021).5. McClelland S 3rd, et al. Rep Pract Oncol Radiother. 28(3):379-388 (2023).6. Van den Brande R, et al. J Bone Oncol. 35:100446 (2022).7. Hamre T, Flores AR, Tom M, et al. Podium presentation at: North American Spine Society (NASS) Annual Meeting; October 2026; San Antonio, TX.8. Glicksman RM, et al. JAMA Oncol. 6(4):567-577 (2020).9. Lee CH, et al. J Korean Neurosurg Soc. 64(1):4-12 (2021).